Van de Ven Brace Halts The Toffees' Run at Brand New Home Ground
Micky van de Ven became the first backline player to net two goals in a Premier League match for Spurs since the Belgian defender in March 2013.
At a glance
Micky Van de Ven nods home twice in opening period
Everton's Jake O'Brien has equalizer disallowed after video check
Pape Matar Sarr scores third in 89th minute
This loss is the Merseyside club's initial at their new ground
The Tottenham defender found the net on two occasions as Spurs prolonged their winning streak in away games in the top division and handed the Toffees their first defeat at their new home.
Everton were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having left Goodison Park behind after 133 years at the end of the previous campaign.
But Spurs captain Van de Ven struck twice from corners in the first half to put their strong form at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - set up by former Toffees attacker Richarlison - nodded in a final goal to put the game to bed.
Jake O'Brien believed he had levelled the tally a short while after Van de Ven's opener, glancing a bullet header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, failed to convert a handful of chances, while the Italian goalkeeper made a succession of excellent saves to guarantee the London club went five away games without defeat in the Premier League.
But the video assistant referee stepped in, advising Craig Pawson to review the score on the pitchside monitor and the referee decided that the winger and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
The win elevates the manager's team into third place in the division, a handful of points off north London rivals and table-toppers Arsenal.
The Merseyside club remain 14th and sit six points clear of the drop zone.
Tottenham analysis: Van de Ven excels in role at each end of the field
Following a uninspiring weekday performance in the European competition against the French side, where they managed a mere attempts on goal, Frank opted for Randal Kolo Muani in attack instead of ex-Everton forward the Brazilian.
The new arrival was unable to make much of an impact before being replaced for the substitute after 60 minutes on the field, but it turns out he wasn't needed in the final outcome.
Centre-back Van de Ven converted into an attacking force to be reckoned with.
Tottenham's opening strike came from a well-worked corner routine, with the midfielder directing the ball toward the six-yard box for an unmarked Van de Ven to score.
And Ven de Ven - filling in as skipper in the Argentine's absence - added his next goal in first-half stoppage time as he outjumped Jordan Pickford to head home.
Van de Ven was just as impressive in defence, combining effectively with Kevin Danso as the duo handled excellently with the 34 crosses sent their way by Everton.
Toffees breakdown: Everton lacking finishing touch
Everton's recent stadium had been a happy hunting ground, but it seems the freshness may have worn off somewhat and fans headed to the gates after Sarr's final goal for Spurs.
The break in the team's winning streak at home won't be a massive concern for David Moyes, but their attacking woes are.
The forward and Thierno Barry - the Toffees' two established centre-forwards - had netted only a single goal between them before Sunday's match.
And they were failed to contribute to that miserable tally on a damp and dreary evening on in Liverpool.
The striker's form was epitomized when he chose to overhead kick a clear chance from near the goal, despite having space and time to reposition for a more conventional attempt that would have tested the keeper.
The substitute, as well, was unable to influence the game after replacing the starter in the second half.
It wasn't for a lack of opportunity. Most of the home side's offensive moves came through Grealish and the forward, who relentlessly whipped dangerous crosses into the Tottenham penalty area.
What next for both teams?
The Toffees: The team head to the Stadium of Light in the Premier League on early November at 20:00 GMT.
Spurs: The London club travel to Newcastle's ground on late October for their next round Carabao Cup match against the Magpies.