The star has given the full amount of his £25k honor prize money to the trust for venues, which works to save the UK's independent concert spaces.
The star was presented with the award on 16 October as his latest record the album was chosen as the top album of the last 12 months.
He has chosen to give the cash to the MVT, in acknowledgment of the essential function local spots fulfilled in his beginning days.
"I couldn't be pursuing what I am doing today if it wasn't for all the gigs I did around the North East, and elsewhere, when I was starting out," said Sam Fender. "These spaces are legendary, but they are facing challenges."
Beginning in 2023, over 150 of these venues have shut down – approximately one-sixth of the entire UK sector.
In the last year, major artists such as Pulp, the group Coldplay, the singer Katy Perry and Sheeran have all aided the trust in its initiatives to support the industry, by applying a minor surcharge to their ticket prices, which benefits independent venues.
Sam Fender also participated, generating in excess of £100,000 on his 2024 arena tour to support 38 local spots across the UK.
The money helped spaces that were dealing with potential shutdown due to difficulties stemming from floods, blazes and family tragedies, as well as regulatory hurdles, legal disputes and sound issues.
Some locations were granted funding support in upgrading infrastructure and technical equipment that positively impacted musicians and concertgoers.
"The concept that funds from shows in major spaces backs the local stages, where it kicks off for musicians like me, is just common sense," Fender has stated.
Fender is among several artists to contribute his Mercury Prize prize money to worthy causes.
When Pulp received the prize in the mid-90s for their record the album, frontman the singer declared that the group would donate their prize money to the non-profit the charity.
That year, musician the artist divided her award among multiple charities, like the children's charity and a charity for Sickle Cell.
"And I donated a thousand pounds to the center, to their gymnastics class, because I practiced gymnastics when I was a child and they needed better apparatus," the artist shared with a publication.
Previously, they contributed their prize money to the community center that supported their act, alongside other independent music bodies.
Also the 1994 recipients they gave their prize to a charity for MS after a close contact was found to have the disease.
"The victory was ample," said singer the singer. "The money was the cherry on top but we didn't require the cherry, because we had the main prize. So our winning impacted another person's life."
In the past week, the Music Venues Trust shared it had protected a couple of small stages in south-east England, by transferring them to public stewardship.
One venue in that area and the second in that location were acquired under the community ownership scheme, which is supported by the arts council and music fans who acquire "ownership units" in the properties.